Human Papillomavirus Integration and its Role in Cervical Malignant Progression
نویسندگان
چکیده
High risk Human Papilloma Virus (HR-HPV) DNA integration into the human genome is one of the key stages in the progression of cervical neoplasia. This mini-review highlights the importance of HPV integration as a potential biomarker for cervical screening and briefly describes the main methods used to detect HPV integration: Amplification of Papillomavirus Oncogene Transcripts (APOT), Restriction Site PCR (RS-PCR), Southern blot and Detection of Integrated Papillomavirus Sequences (DIPS). The potential mechanisms of HPV integration are discussed with a focus on DNA instability; site of integration; and transcriptional regulation of integrants. This article provides an overview of the role HPV integration plays in malignant progression.
منابع مشابه
Human Papillomavirus Integration: The Mechanism(s) Behind the High-Risk Associated with this Event and Cervical Disease Progression
High risk Human Papilloma Virus (HR-HPV) DNA integration into the human genome isone of the key stages in the progression of cervical neoplasia. This mini-review highlights theimportance of HPV integration as a potential biomarker for cervical screening and brieflydescribes the main methods used to detect HPV integration: Amplification of PapillomavirusOncogene Transcripts (APOT...
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